A new formulation comprising nanogels conjugated with insulin molecules (NG-In) has been developed to be used for Alzheimer Disease (AD) therapy. Nanogels (NGs) are an emerging class of nanocarriers characterized by water-swollen, nanosized three-dimensional networks. The family of synthetized nanogels is characterized by a lightly crosslinked structure, based on poly (N-vinyl pyrrolidone), and multiple functionalities including carboxylic and primary amino groups.
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The results of tecnological research are rapresented by the identification of enzimatic activities and microorganism able to degrade contaminants in raw material and food. The identification has been performed by using both a classical microbiological approach and the analysis of Next Generation Sequencing data. Microorganism were selected based on their ability of survive and adapt to polluted environments. Growth assays and chemical and transcriptomic analysisin the presence of the pollutant were performed in order to identify the enzymes responsible for degradation.
Here a Silica Gelatin composite for removal of chromate from water solutions and the “in situ” conversion process of Cr(VI) to Cr(III) onto this material are described. All the fabrication details of this composite are also described. Additionally we also determine that chromate ions adsorption is not affected by the presence of sulfate ions and a slightly acidic pH conditions
ISAFOM-CNR, Perugia has recently developed an innovative procedure that can easily turn the waste resulting from olive oil mills into an excellent soil conditioner/organic fertilizer.
It is realized through a simplified static composting procedure conducted in gas-permeable bags with passive aeration of the biomass.
The technology is especially suited to the treatment of the humid pomace produced by “two phases” modern olive mills, ideally working in line with it.
Biocompatible, biodegradable, non-toxic, and bioresorbable nanoparticles for the delivery of therapeutic or diagnostic compounds to the heart. The nanoparticles are characterized by a particular affinity for cardiac cells and can be administered via enteral and parenteral routes.
Being able to encapsulate and/or conjugate one or more therapeutic/diagnostic compounds, the nanoparticles can be used in the pharmaceutical industry for the delivery of therapeutic compounds and/or diagnostic to the heart for the treatment of acute or chronic pathological conditions.
The technology is based on the optical properties of the biomolecules naturally present in the tissues (endogenous fluorofores), able to give rise to autofluorescence (AF) signals when excited by a light at suitable wavelength.
AIM: To design and validate a multiparametric platform that allows the simultaneous detection of multiple immunohistochemical markers for CRC, by combining different positive or negative indicators, with the aim of developing a diagnostic/prognostic tool more specific, than those currently available.
It is a technology which allows to register SAXS scanning microscopies: an hard X-ray beam, focused by proper optics, illuminates consecutive area of a sample, with a 2D detector – placed at a proper distance from sample - registering the signal diffracted from each illuminated area, in the small angle scattering range (SAXS). At the end of the acquisition, data are composed together in quantitative microscopy, using specific crystallographic and statistic approaches.
The proposed technology is based on the endogenous mechanisms regulating cellular homeostasis and, in particular, on mechanisms that control cell proliferation and apoptosis.
From a molecular point of view, the methodological approach is based on the design of RNA suitable for gene silencing, the so-called small interfering RNAs/siRNAs.
Once delivered to the cells as such or as shRNA using suitable vectors (also inducible), these siRNA are able to induce the alternative translation of the specific mRNA target.